Consequências neurológicas do uso abusivo de esteróides anabolizantes androgênicos

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Palavras-chave

esteróides anabolizantes
hormônios
neurologia
psiquiatria
efeitos adversos anabolic steroids
hormones
neurology
psychiatry esteroides anabólicos
hormonas
neurología
psiquiatría
efectos adversos.

Como Citar

Gomides, L., Oliveira, L. A., Mayers, N., Lacerda, F. B., Santos, J. P. B., Filho, B. B., Assunção, I. N., Cupertino, M., & Santana, M. G. (2024). Consequências neurológicas do uso abusivo de esteróides anabolizantes androgênicos. Tempus – Actas De Saúde Coletiva, 13(1), 102–122. https://doi.org/10.18569/tempus.v13i1.2700 (Original work published 29º de dezembro de 2023)

Resumo

O abuso de esteróides anabólicos androgênicos (EAAs) está associado a altas taxas de morbidade e mortalidade. A maior incidência desta negligência documentada em homens (taxa de prevalência de cerca de 6,4%), um terço dos quais desenvolvem reações adversas. Nesse sentido, o objetivo foi revisar os estudos publicados sobre as complicações neurológicas desencadeadas pelo uso indiscriminado de EAAs, com foco na patogênese das lesões no sistema nervoso (SN). Como resultado observou-se que no SN, esses estimulantes atuam por meio de sistemas de sinalização complexos que incluem a alteração neuroendócrina do eixo hipotálamo-hipófise-gonadal, modificação de neurotransmissores e seus receptores, bem como a indução de morte neuronal por apoptose em vários caminhos. Estas alterações neurológicas orgânicas podem levar a uma sintomatologia clínica com alterações neurológicas, do humor e do sono. Conseqüentemente, foram observados efeitos adversos variados de acordo com a classe de AAS utilizada, forma de administração e tempo de uso. Mesmo assim, até o momento, apenas algumas classes foram submetidas a análises científicas, quanto a dosagens, modo de administração e tempos específicos de exposição. Além disso, o uso e a produção ilegais dessas drogas não propiciam sua adequada aplicação, controle de qualidade e pureza. Concluiu-se que o abuso de AAS tem efeitos inimigas graves e complexos, incluindo graves problemas neurotóxicos.

https://doi.org/10.18569/tempus.v13i1.2700
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