Versões
- 2024-01-03 (2)
- 2023-12-29 (1)
Palavras-chave
hormones
neurology
psychiatry esteróides anabolizantes
hormônios
neurologia
psiquiatria
efeitos adversos esteroides anabólicos
hormonas
neurología
psiquiatría
efectos adversos.
Como Citar
Resumo
O abuso de esteróides anabólicos androgênicos (EAAs) está associado a altas taxas de morbidade e mortalidade. A maior incidência desta negligência documentada em homens (taxa de prevalência de cerca de 6,4%), um terço dos quais desenvolvem reações adversas. Nesse sentido, o objetivo foi revisar os estudos publicados sobre as complicações neurológicas desencadeadas pelo uso indiscriminado de EAAs, com foco na patogênese das lesões no sistema nervoso (SN). Como resultado observou-se que no SN, esses estimulantes atuam por meio de sistemas de sinalização complexos que incluem a alteração neuroendócrina do eixo hipotálamo-hipófise-gonadal, modificação de neurotransmissores e seus receptores, bem como a indução de morte neuronal por apoptose em vários caminhos. Estas alterações neurológicas orgânicas podem levar a uma sintomatologia clínica com alterações neurológicas, do humor e do sono. Conseqüentemente, foram observados efeitos adversos variados de acordo com a classe de AAS utilizada, forma de administração e tempo de uso. Mesmo assim, até o momento, apenas algumas classes foram submetidas a análises científicas, quanto a dosagens, modo de administração e tempos específicos de exposição. Além disso, o uso e a produção ilegais dessas drogas não propiciam sua adequada aplicação, controle de qualidade e pureza. Concluiu-se que o abuso de AAS tem efeitos inimigas graves e complexos, incluindo graves problemas neurotóxicos.
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